Linda Lallawmsangi / Chemistry & Biochemistry / Faculty Mentor: Junha Jeon
Ester reduction to aldehydes is challenging as the resulting aldehydes are often more reactive than the initial esters toward nucleophilic hydride reducing agents.For this reason, bulky reducing agents have been developed, such as lithium tri-tert-butoxyaluminum hydride or diisobutylaluminum hydride (DIBALH).When diethylsilane is employed as a reductant, it is possible to catalytically reduce C=O double bonds using readily available iridium catalysts such [Ir(COE)2Cl]2. We sought to design a catalytic system that would hydrolyze the silyl group upon chemo- and stereoselective hydrosilylation of dicarboxylic imides.
Leave a Reply